Determinants of extracellular protein secretion in gram-negative bacteria

Determinants of extracellular protein secretion in gram-negative bacteria.

Protein localization has been the subject of extensive research using models ranging from bacteria to mammalian cells. The central question which prokaryoticand eukaryotic-cell biologists have attempted to answer is how proteins synthesized in the cytoplasmic compartment traverse the hydrophobic membrane barrier or become integrated into it. This work has led to the identification of targeting ...

Protein Secretion Systems in Gram-Negative Bacteria

P rotein export systems are present in all living organisms, including gram-negative bacteria and the eukaryotic organelles that derived from them (Table 1). In contrast to other organisms, however, gram-negative bacteria contain numerous, apparently independent systems for exporting proteins, including at least eight types that mediate export across or insertion into the inner cytoplasmic memb...

Antibiotic Resistance Pattern of Gram-Negative Bacteria in Gorgan

Abstract Background and Objective: The excessive use of broad-spectrum antibiotics will lead to drug resistance of microorganism and specially nosocomial organisms. Because of high incidence of antibiotic resistance in hospitals, we aimed to study antibiotic resistance to gram negative bacteria. Material and Methods: This cross-sectional study was conducted on the data of biological sampl...

Cell Envelope Structure and Functions in Gram-negative Bacteria

Super-Resolution Imaging of Protein Secretion Systems and the Cell Surface of Gram-Negative Bacteria

Gram-negative bacteria have a highly evolved cell wall with two membranes composed of complex arrays of integral and peripheral proteins, as well as phospholipids and glycolipids. In order to sense changes in, respond to, and exploit their environmental niches, bacteria rely on structures assembled into or onto the outer membrane. Protein secretion across the cell wall is a key process in virul...